15th Jenner Glycobiology and Medicine Symposium

14-16 June 2023 | Porto, Portugal

Program

Wednesday 14th

Thursday 15th

Friday 16th

Schedule

13:30-14:00

14:00-14:20

14:20-15:00

15:00-15:20

15:20-15:30

15:30-15:40

15:40-16:20

16:20-17:00

17:00-17:20

17:20-17:30

17:30-17:40

17:40-18:00

18:00

Session

Registration

Welcome Session

Plenary Lecture 1: Max Crispin, University of Southampton

Selected Talk 1

Speed Talk 1

Speed Talk 2

Coffee Break

Plenary Lecture 2: Sandra van Vliet, Amsterdam University Medical Center

Selected Talk 2

Speed Talk 3

Speed Talk 4

Selected Talk 3

Porto D’Honra

Schedule

09:00-09:40

09:40-10:00

10:00-10:10

10:10-10:20

10:20-11:00

11:00-11:40

11:40-12:00

12:00-12:10

12:10-12:20

12:20-12:30

12:30-12:40

12:40-12:45

12:45-14:00

14:00-14:20

14:20-14:30

14:30-14:40

14:40-16:20

16:20-17:00

Session

Plenary Lecture 3: Katrine T. Schjoldager, University of Copenhagen

Selected Talk 4

Speed Talk 5

Speed Talk 6

Coffee Break

Plenary Lecture 4: Christian Bull, Radboud University

Selected Talk 5

Speed Talk 7

Speed Talk 8

Speed Talk 9

Speed Talk 10

Merck communication

Lunch

Selected Talk 6

Speed Talk 11

Speed Talk 12

Poster Session + Coffee Break

Plenary Lecture 5: Robert Sackstein, Florida International University

Schedule

09:00-09:40

09:40-10:00

10:00-10:10

10:10-10:20

10:20-11:00

11:00-11:40

11:40-12:00

12:00-12:10

12:10-12:20

12:20-12:40

12:40-14:00

14:00-14:20

14:20-14:30

14:30-14:40

14:40-15:40

15:40-16:00

Session

Plenary Lecture 6: Lucy Crouch, University of Birmingham

Selected Talk 7

Speed Talk 13

Speed Talk 14

Coffee Break

Plenary Lecture 7: Romain Vivés, Université Grenoble Alpes

Selected Talk 8

Speed Talk 15

Speed Talk 16

EIC Pathfinder challenge

Lunch

Selected Talk 9

Speed Talk 17

Speed Talk 18

Lecture and Interview with Prof. Sir Roy Anderson, Imperial College

Closing Ceremony

20:00 Conference Dinner


Wednesday 14th June

13:30-14:00 Registration

14:00-14:20 Welcome Session

Claudio Sunkel, John Axford & Celso Reis

Chairs: John Axford (St. George’s University of London) & Celso Reis (i3S, University of Porto)

14:20-15:00 PLENARY LECTURE 1

Exploiting pathogen immune evasion strategies in vaccine design and therapeutics

Max Crispin, Molecular and Cellular Biosciences, University of Southampton, United Kingdom

15:00-15:20 SELECTED TALK 1

Helicobacter pylori attachment-blocking antibodies in protection against gastric disease

Thomas Borén, Umeå University, Sweden

15:20-15:30 SPEED TALK 1

Bivalent binding of FimH by an N-glycan in the crystal gives clues on the structural constraints of multivalent anti-adhesives for uropathogenic and Crohn’s disease-associated Escherichia coli

Julie Bouckaert, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), France

15:30-15:40 SPEED TALK 2

Targeting cell wall glycosylation to disarm and sensitize Gram-positive pathogens

Didier Cabanes, i3S, University of Porto, Portugal

15:40-16:20 Coffee Break

Chairs: Henrik Clausen (University of Copenhagen) & Joana Gomes (i3S, University of Porto)

16:20-17:00 PLENARY LECTURE 2

Tumor-associated glycan structures: friend or foe in immunity to cancer?

Sandra van Vliet, Amesterdam UMC, Universitair Medische Centra, Netherlands

17:00-17:20 SELECTED TALK 2

Towards a better understanding of the multiple levels of Sda and sLex regulated expression in the human digestive tract

Anne Harduin-Lepers, CNRS-Université de Lille, France

17:20-17:30 SPEED TALK 3

Polypeptide GalNAc-transferase-13 expression is involved in lung adenocarcinoma drug resistance

Eduardo Osinaga, Institut Pasteur de Montevideo, Uruguay

17:30-17:40 SPEED TALK 4

Glycan-dependent signaling and transcriptional programs in human dendritic cells upon triggering of the C-type lectin receptor MGL

Nadia van der Meijs, Amsterdam UMC, Netherlands

17:40-18:00 SELECTED TALK 3

Mind the GAGs in gastric cancer

Ana Magalhães, ICBAS / i3S, University of Porto, Portugal

18:00 Porto D’Honra

Thursday 15th June

Chairs: Nico Callewaert (University of Ghent) & Daniela Freitas (i3S, University of Porto, Portugal)

09:00-09:40 PLENARY LECTURE 3

Map of Neuronal Tissue O-glycosites Reveal specific traits in the Secretogranin Family

Katrine T Schjoldager, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

09:40-10:00 SELECTED TALK 4

Integrated Design Antibody Libraries (iDEAL) for targeting elusive glycopeptide combotopes

Klas Ola Blixt, Technical University of Denmark, Denmark

10:00-10:10 SPEED TALK 5

Development and Characterization of two novel Antibodies against Sialyl Lewis A

Anika Freitag, Max Planck Institute of Colloids and Interfaces, Germany

10:10-10:20 SPEED TALK 6

ST6Gal1 Modifies ErbB2 Trastuzumab-Binding Domain in a Site-Specific Manner to Support Molecular Resistance to Trastuzumab

Henrique Oliveira Duarte, i3S, University of Porto, Portugal

10:20-11:00 Coffee Break

Chairs: Katrine T. Schjoldager (University of Copenhagen, Copenhagen Center for Glycomics ) & Henrique Duarte (i3S, University of Porto, Portugal)

11:00-11:40 PLENARY LECTURE 4

Cell-based display of the human sialome

Christian Büll, Institute for Molecules and Materials – Radboud University, Netherlands

11:40-12:00 SELECTED TALK 5

The generation of cancer-specific ribosomes by the lncRNA LISR suppresses melanoma anti-tumour immunity

Eleonora Leucci, KU Leuven, Belgium

12:00-12:10 SPEED TALK 7

Long-Acting-GlycoDesign of Lysosomal Replacement Enzymes

Yen-Hsi Chen, University of Copenhagen and GlycoDisplay ApS, Denmark

12:10-12:20 SPEED TALK 8

Glycoproteogenomic Characterization of CD44 Splicing in Bladder Cancer: Implications for Precision Oncology and Vaccine Development

José Alexandre Ferreira, Portuguese Institute of Oncology of Porto, Portugal

12:20-12:30 SPEED TALK 9

Use of a metabolic oligosaccharide engineering to study the regulation of glycosylation in the secretory pathway by the cytosolic O-GlcNAcylation

Jodie Scache, CNRS-Université de Lille, France

12:30-12:40 SPEED TALK 10

The importance of glycosylation in resistance to therapy – gastric tumor organoids as a model

Filipe Pinto, i3S, University of Porto, Portugal

12:40-12:45 Merck communication

12:45-14:00 Lunch

Chairs: Anne Harduin-Lepers (CNRS-Université de Lille) and Catarina Gomes (i3S, University of Porto, Portugal)

14:00-14:20 SELECTED TALK 6

Specific fucosyltransferases inhibition using fucose mimetics

Barbara Richichi, University of Florence, Italy

14:20-14:30 SPEED TALK 11

N-glycan profiles of microsatellite unstable colorectal cancers are dependent on stage and BRAF mutation status

Pirjo Nummela, University of Helsinki and Helsinki University Hospital, Finland

14:30-14:40 SPEED TALK 12

The ST6Gal1/Siglec-10 glyco-immune checkpoint in colorectal cancer immune evasion

Joana Gomes, i3S, University of Porto, Portugal

14:40-16:20 POSTER SESSION + Coffee Break

Chairs: Pauline Rudd (University College Dublin) and Celso Reis (i3S, University of Porto, Portugal)

16:20-17:00 PLENARY LECTURE 5

Unveiling the Glycobiology of Human Hematopoietic Development

Robert Sackstein, Herbert Wertheim College of Medicine, Florida International University, USA

20:00 Conference Dinner

Friday 16th June

Chairs: Roisin O’Flaherty (Maynooth University) and Alexandre Ferreira (IPO-Porto)

09:00-09:40 PLENARY LECTURE 6

Breakdown of carbohydrates by human gut commensals and pathogens

Lucy Crouch, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, United Kingdom

09:40-10:00 SELECTED TALK 7

Immunogenic Campylobacter jejuni conjugate vaccines prepared with TEMPO-activated polysaccharide capsules

Mario Monteiro, University of Guelph, Canada

10:00-10:10 SPEED TALK 13

Fusobacterium nucleatum ssp. and Siglec-7 interaction in immunomodulation

Dimitra Lamprinaki, Quadram Institute Bioscience, United Kingdom

10:10-10:20 SPEED TALK 14

Molecular characterization of O-glycan selective proteins from human commensal bacteria

Benedita Andrade Pinheiro, UCIBIO/i4HB/FCT-NOVA, Portugal

10:20-11:00 Coffee Break

Chairs: Rita Gerardy-Schann (Hannover Medical School) and Ana Magalhães (i3S, University of Porto, Portugal)

11:00-11:40 PLENARY LECTURE 7

Sulfs: post-synthesis regulators of heparan sulfate

Romain Vivès, Université Grenoble Alpes, France

11:40-12:00 SELECTED TALK 8

Glycans’ Immunomodulatory Role in Aberrant to Defective Glycosylation: Potential Therapeutic Targets and Biomarkers

Paula Videira, NOVA School of Science and Technology, Portugal

12:00-12:10 SPEED TALK 15

Effects of Testosterone and Metformin on IgG Glycome Composition in Men with Obesity

Martina Vinicki, Genos Ltd, Croatia

12:10-12:20 SPEED TALK 16

Monensin disrupts the synthesis of SLeX in tumors and influences its malignant features

Catarina Gomes, i3S, University of Porto, Portugal

12:20-12:40 EIC Pathfinder challenge: Precision nutrition

Ivan Stefanic, EIC Programme Manager for Food Chain Technologies and Novel & Sustainable Food

12:40-14:00 Lunch

Chairs: Claudine Kieda (CBM-CNRS) and Paula Videira (NOVA School of Science and Technology)

14:00-14:20 SELECTED TALK 9

Turning universal O into rare Bombay type blood

Marcelo Guerin, Ikerbasque – Basque Foundation for Science, Spain

14:20-14:30 SPEED TALK 17

Targeting hypersialylation in pancreatic ductal adenocarcinoma to reverts their malignant phenotype

Pedro Enrique Guerrero, University of Zaragoza, Spain

14:30-14:40 SPEED TALK 18

TMTC1-4 driven O-mannosylation in ovarian cancer invasiveness

Katarina Madunić, University of Copenhagen, Copenhagen

Interviewer: John Axford (St. George’s University of London)

14:40-15:40 Lecture and Interview

Prof. Sir Roy Anderson, Faculty of Medicine, School of Public Health, Imperial College, United Kingdom

15:40-16:00 Closing Ceremony

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